The aim of the study was to investigate various psychophysiological predictors of the quality of monotonous activity performance against the background of sleep deprivation. Fourteen subjects aged 18–22 years took part in the experiments. Each subject participated in four experimental sessions with partially automated control scenarios in a computerized driving simulator: the first experiment (15 minutes) – training session in the simulator without sleep deprivation; the second experiment – sleep deprivation (90 minutes); the third experiment – sleep deprivation and periodic exposure to a massage seat cover (90 minutes); the fourth experiment – sleep deprivation and periodic spraying of peppermint oil from an aroma diffuser (90 minutes). Every 3–7 minutes, subjects were asked to respond to two types of stimuli: 1) gradually changing; 2) appearing unexpectedly and requiring maneuvering. Stimulus intervals and stimulus order were varied randomly. Car driving simulator data, electroencephalogram using the standard 10–20 system with a sampling rate of 1000 Hz, electrocardiogram and skin-galvanic response were recorded. A three-dimensional video camera was mounted on a monitor in front of the subject to track head position and changes of the subject’s facial expressions throughout the experiment. Subjects completed questionnaires on sleepiness and general well-being, and reaction time was also tested before the experiment. According to the results of the questionnaires and test performance, the subjects were in a state of chronic sleep deprivation and chronic stress. No statistically significant differences between the experiments after partial sleep deprivation without additional stimulation, with the use of a massage seat cover and periodic spraying of peppermint oil every 10 minutes were seen. The eye closure rate (PERCLOS) and spectral index of heart rate variability showed a significant statistically reliable increase before errors. The values of physiological indices before errors indicate different causes of errors in experiments without and with exposure to peppermint oil or massage seat cover.