The article discusses the prospects of applying the scientific research and practical methods in the field of allelopathy for the weed control and combating the invasions based on the analysis of literary sources of 2017–2021. The development of the organic segment of agricultural production stimulates research in the field of environmentally friendly methods of plant protection. Studies of the allelopathic activity of grain crops have found significant heterogeneity on this basis in varieties, wild species and precursors of cultural forms. The creation of high-yielding varieties with allelopathic activity by modern accelerated breeding methods is at the stage of promising developments. The first organic (biorational) herbicides were created based on models of molecular structures of plant allelochemics. The article discusses the disadvantages and advantages of organic herbicides, current directions of scientific research in this field. The success of plant invasions has recently been associated with a possible allelopathic advantage of alien species. Scientific developments in the field of invasion control include the induction of biochemical protective mechanisms of local flora, the search for native species resistant to invaders’ allelochemics, monitoring the balance of exometabolites in the forest litter, the creation of “plant matrix” resistant to alien invasion and weed species attack. In the field of innovative urban landscaping based on allelopathy, methods for creating weed-resistant plantings have been developed and tested.